Arai, Masayoshi and Ishida, Shunsuke and Setiawan, Andi and Kobayashi, Motomasa (2009) Haliclonacyclamines, Tetracyclic Alkylpiperidine Alkaloids, as Anti-dormant Mycobacterial Substances from a Marine Sponge of Haliclona sp. Chem. Pharm. Bull..

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Abstract

A new tetracyclic alkylpiperidine alkaloid, 22-hydroxyhaliclonacyclamine B (1), together with two known al�kaloids, haliclonacyclamine A (2) and B (3), were isolated from a marine sponge of Haliclona sp. as anti-dormant mycobacterial substances. The chemical structure of 22-hydroxyhaliclonacyclamine B (1) was determined on the basis of spectroscopic study. The compounds 2 and 3 showed strong anti-mycobacterial activity against Mycobac�terium smegmatis and M. bovis Bacille de Calmette et Guérin (BCG) under both aerobic condition and hypoxic condition inducing dormant state with minimum inhibitory concentrations (MICs) in the ranges of 1.0— 2.5 mg/ml. In addition, the anti-microbial activity of compound 3 was bactericidal against M. bovis BCG under both aerobic and hypoxic conditions. The 22-hydroxy group in 1 was found to reduce anti-mycobacterial activity, because 22-hydroxyhaliclonacyclamine B (1) exhibited weaker anti-microbial activities against Mycobacterium bacilli with MICs in the ranges of 12.5—50 mg/ml

Item Type:	Other
Subjects:	Q Science > Q Science (General)
Depositing User:	Prof Andi Setiawan
Date Deposited:	14 Feb 2022 01:45
Last Modified:	14 Feb 2022 01:45
URI:	http://repository.lppm.unila.ac.id/id/eprint/39174

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