Arai, Masayoshi and Han, Chisu and Yamano, Yoshi and Setiawan, Andi and Kobayashi, Motomasa (2014) Aaptamines, marine spongean alkaloids, as anti-dormant mycobacterial substances. J Nat Med, 68 (2). pp. 372-376. ISSN 13403443, 18610293
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Abstract
A new aaptamine class alkaloid, designated 2-methoxy-3-oxoaaptamine (1), together with seven known aaptamines (2–8) were isolated from a marine sponge of Aaptos sp. as anti-mycobacterial substances against active and dormant bacilli. The chemical structure of 1 was determined on the basis of spectroscopic analysis. Com�pound 1 was anti-mycobacterial against Mycobacterium smegmatis in both active growing and dormancy-inducing hypoxic conditions with a minimum inhibitory concentra�tion (MIC) of 6.25 lg/ml, and compounds 2, 5, 6, and 7 showed anti-mycobacterial activities under hypoxic con�dition selectively, with MIC values of 1.5–6.25 lg/ml. Keywords Aaptamine � Marine sponge � Anti-mycobacterial activity � Dormant � Tuberculosis
| Item Type: | Article |
|---|---|
| Subjects: | Q Science > Q Science (General) |
| Divisions: | Fakultas Matematika dan Ilmu Pengetahuan Alam (FMIPA) > Prodi Kimia |
| Depositing User: | Prof Andi Setiawan |
| Date Deposited: | 09 Jun 2021 01:01 |
| Last Modified: | 09 Jun 2021 01:01 |
| URI: | http://repository.lppm.unila.ac.id/id/eprint/32373 |
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