Mumtazah, Dzul Fithria and Listiyaningsih, Erlin and Wijayanti, Nastiti (2020) T512C AND T-123/IN1C SNP PLA2G10 GENOTYPE IN ANGINA PECTORIS PATIENTS AT NATIONAL CARDIOVASCULAR CENTER HARAPAN KITA JAKARTA, INDONESIA. Biota Jurnal Ilmu Ilmu Hayati, 6 (1). ISSN 2527-3231 (Submitted)
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Abstract
Angina Pectoris is one of the early symptoms which is a marker of severe cardiovascular problems such as coronary heart disease. The PLA2G10 gene is believed to play a role whether in the atherosclerotic progression that causes plaque deposits which clog the coronary arteries of the heart or otherwise, antiatherogenic. PLA2G10 polymorphism at SNP ID T512C (rs36072688) and T-123/in1C (rs4003232) play the role in altered the expression level of PLA2G10 as sPLA2-GX coding gene which cause the rapid plaque progression in some groups of animal model and decrease it in some other.The objection of this research is to determine the genotype of PLA2G10 gene in angina pectoris patients of National Cardiovascular Center Harapan Kita in order to define if the disease occurs because of the mutation. The research samples are 133 deposit biological materials (peripheral blood mononuclear cell) from National Cardiovascular Center Harapan Kita’s collection, from angina pectoris patients with plaque and non plaque in the coroner. The polymorphism was determined by TaqMan® SNP Genotyping Assay. The result shows that all the samples from angina pectoris patients in National Cardiovascular Harapan Kita have genotype homozigot wildtype (TT) at SNP ID T512C (rs36072688) and heterozygot (TC) at T-123/In1C (rs4003232) PLA2G10 gene and there’s no polymorphism found in two groups of sample.
| Item Type: | Article |
|---|---|
| Subjects: | Q Science > QL Zoology Q Science > QM Human anatomy |
| Divisions: | Fakultas Matematika dan Ilmu Pengetahuan Alam (FMIPA) > Prodi Biologi |
| Depositing User: | Dzul Fithria Mumtazah |
| Date Deposited: | 07 Dec 2020 01:24 |
| Last Modified: | 07 Dec 2020 01:24 |
| URI: | http://repository.lppm.unila.ac.id/id/eprint/27015 |
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