Medikanto Rahmadi, Dian and Setyaningrum, Endah (2013) PENGARUH EKSTRAK DAUN LEGUNDI ( Vitex trifolia L. ) SEBAGAI REPELLENT TERHADAP NYAMUK Aedes aegypti. Jurnal Kedokteran, 2 (4). pp. 35-43. ISSN 2337-3776

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Abstract

Abstrak Demam berdarah merupakan infeksi yang ditularkan melalui nyamuk yang ditemukan di daerah tropis dan sub - tropis di seluruh dunia. Penularan demam berdarah telah meningkat dan telah menjadi masalah kesehata n besar bagi masyarakat internasional. Salah satu vektor utama demam berdarah adalah Aedes aegypti . Demam berdarah ditularkan oleh gigitan nyamuk Aedes aegypti yang terinfeksi virus demam berdarah. Penggunaan repellent untuk mencegah gigitan nyamuk dapat m emberikan perlindungan penting dari vektor demam berdarah. DEET, sebuah repellent umum yang telah digunakan di seluruh dunia telah dilapor kan memiliki kekurangan dan dik awatirkan atas toksisitasnya. Dengan demikian, diperlukan evaluasi repellent alami dari tumbuhan untuk menambah metode pengendalian konvensional. Fitokimia dari Vitex trifolia telah dilaporkan memiliki aktivitas sebagai repellent . Penelitian ini dilakukan untuk mengevaluasi aktivitas repellent dari ekstrak daun Vitex trifolia terhadap Aedes aegypti. Periode penelitian dilakukan pada bulan Nopember sampai dengan Desember 2012. Untuk me ngetahui dosis efektif dari ekstrak daun Vitex trifolia , dilakukan pengujian repellent berdasarkan prosedur yang direkomendasikan oleh World Health Organization Pesticides Evaluation Scheme (WHOPES). Setiap ekstrak daun Vitex trifolia diencerkan menjadi (10%, 20%, dan 30%) dengan alkohol (70%) dan di aplikasikan pada lengan bawah relawan. Tangan ditutupi dengan dua sarung tangan nitril. Alkohol (70%) berfungsi seb agai kontrol negatif. Nilai dosis efektif untuk daya proteksi terhadap Aedes aegypti sebesar 50% dan 99% (ED 50 dan ED 99 ) dihitung dengan analisis probit. Hasil menunjukkan nilai ED 50 adalah 14, 809% dan nilai ED 99 adalah 41, 423% terhadap Aedes aegypti . Ekst rak daun Vitex trifolia menunjukkan aktivitas repellent terhadap Aedes aegypti . Kata kunci: daun Vitex trifolia , Aedes aegypti , repellent , dosis efektif INFLUENCE OF Vitex trifolia L . LEAF EXTRACTS AS REPELLENT AGAINST Aedes aegypti Bian Rahmadi Medikanto 1) , Dra. Endah Setyaningrum , M.Biomed 2) 1) Medical Faculty Student of Lampung Univesity, 2) Medical Faculty Lecturer of Lampung University Abstract Dengue is a mosquito - borne infection found in tropical and sub - tropical regions around the world. Dengue tran smission is increased and has become a major international public health concern. One primary carrier of Dengue is Aedes aegypti . Dengue is transmitted by the bite of an Aedes mosquito that already infected with dengue viruses. Use of repellents to prevent mosquito bites may provide important protection from Dengue carriers. DEET, a commercial repellent that already known and used globally has been reported for its disadvantages and toxicity. Thus, there are more things that need to be evaluated plant - based repellents in order to supplement conventional control methods. Phytochemicals of Vitex trifolia have bee n reported on repellent action. The study was conducted to evaluate the repellent activity of the Vitex trifolia leaf extracts against Aedes aegypti . The period o f study was from November to Dec ember 2012. To estimate the effective dose of Vitex trifolia leaf extracts, repellency tests were carried out following procedures recommended by the World Health Organization Pesticides Evaluation Scheme (WHOPES ). Each Vitex trifolia leaf extracts was diluted (10%, 20%, and 30%) in alcohol (70%) and applied to the forearm of the volunteer. The hand was covered with two nitrile gloves. Alcohol (70%) served as a negative control. Effective dose for percent protecti on 50 % and 99 % (ED 50 and ED 99 ) againts Aedes aegypti were calculated by probit statistic software. T he result showed that values of ED 50 were 14.809% and values of ED 99 were 41.423% for Aedes aegypti . Vitex trifolia leaf extracts showed repellent action ag ainst Aedes aegypti . Keywords: Vitex trifolia leaf , Aedes aegypti , repellent, effective dose

Item Type:	Article
Subjects:	A General Works > AC Collections. Series. Collected works
Divisions:	Fakultas Kedokteran (FK) > Prodi Pendidikan Dokter
Depositing User:	Fertika Dwi Yoswita
Date Deposited:	30 Jun 2016 07:13
Last Modified:	14 Jul 2016 05:35
URI:	http://repository.lppm.unila.ac.id/id/eprint/90

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