Arai, Masayoshi and Kamiya, Kentaro and Shin, Dayoung and Matsumoto, Hirokazu and Hisa, Tomoya and Setiawan, Andi and Kotoku, Naoyuki and Kobayashi, Motomasa (2016) N-Methylniphatyne A, a New 3-Alkylpyridine Alkaloid as an Inhibitor of the Cancer Cells Adapted to Nutrient Starvation, from an Indonesian Marine Sponge of Xestospongia sp. Chemical and Pharmaceutical Bulletin, 64 (7). pp. 766-771. ISSN 1347-5223
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Abstract
In the course of searching for selective growth inhibitors of the cancer cells adapted to nutrient starvation, a new 3-alkylpyridine alkaloid named N-methylniphatyne A (1) was isolated from an Indonesian marine sponge of Xestospongia sp. The chemical structure of 1 was determined on the basis of the spectroscopic analysis and comparison with the synthesized 1 and its analogues. Compound 1 showed the cytotoxic activity against PANC-1 cells under the condition of glucose starvation with IC50 value of 16 μM, whereas no growth inhibition was observed up to 100 μM under the general culture conditions.
| Item Type: | Article |
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| Additional Information: | # These authors contributed equally to this work. |
| Subjects: | Q Science > QD Chemistry |
| Divisions: | Fakultas Matematika dan Ilmu Pengetahuan Alam (FMIPA) > Prodi Kimia |
| Depositing User: | Prof Andi Setiawan |
| Date Deposited: | 25 Jun 2018 02:22 |
| Last Modified: | 25 Jun 2018 02:22 |
| URI: | http://repository.lppm.unila.ac.id/id/eprint/7625 |
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