Soemarwoto, Retno A S and mustofa, syazili and sukarti, sukarti (2025) SERUM METALLOPRETEINASE 3 (MMP-3) LEVELS IN LUNG CANCER AND CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD) PATIENTS. Jurnal Aisyah : Jurnal Ilmu Kesehatan, 10 (1). pp. 344-352. ISSN 2502-9495

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Abstract

Chronic Obstructive Pulmonary Disease (COPD) and lung cancer are among the leading causes of mortality and share a similar genetic predisposition. COPD is recognized as a significant risk factor for lung cancer. Matrix metalloproteinases (MMPs) degrade the extracellular matrix (ECM) and contribute to tissue damage by activating cytokines such as tumor necrosis factor (TNF), thereby exacerbating inflammation and cellular damage characteristic of COPD pathogenesis. Several inclusion criteria were applied in this study, including healthy individuals as controls, patients diagnosed with lung cancer confirmed through histopathological examination, and lung cancer patients with coexisting COPD. Matrix metalloproteinase-3 (MMP-3) is a protein involved in cancer progression and is believed to play a role in the transition from COPD to lung cancer. This descriptive observational study aimed to compare plasma MMP-3 levels among four groups: healthy individuals, lung cancer patients, COPD patients, and patients with both lung cancer and COPD. The study included 40 participants, selected using a total sampling technique. The findings revealed that plasma MMP-3 levels were lowest in the healthy group and elevated in the other groups. The increase in plasma MMP-3 levels among patients suggests a potential association between serum MMP-3 levels and the development of lung cancer in COPD patients. Abnormal MMP activity induces pathological metabolic cascades, which can trigger complex cellular changes leading to tumorigenesis. However, further research is required to better understand this relationship. Keywords: Chronic Obstructive Pulmonary Disease, Lung Cancer, Matrix Metalloproteinase-3.

Item Type:	Article
Subjects:	R Medicine > R Medicine (General)
Divisions:	Fakultas Kedokteran (FK) > Prodi Pendidikan Dokter
Depositing User:	Dr.Si. dr. Syazili Mustofa
Date Deposited:	02 Jun 2025 01:36
Last Modified:	02 Jun 2025 01:36
URI:	http://repository.lppm.unila.ac.id/id/eprint/54597

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