Hadi, Sutopo The Antimalarial Activity of Some Organotin(IV) benzoate against Plasmodiun falcifarum. In: International Conference on, July 13-15, 2017, Bandar Lampung.

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Abstract

The strong biological activity of organotin(IV) carboxylate and its derivatives have long been known, and most of them are active even at very low concentration making these compounds continue to attract more attention to be explored. In this paper, we report the antimalarial activity of some organotin(IV) benzoate compounds following and continuing our success in the syntheses and activity studies of some organotin(IV) carboxylates in our previous investigation, the initial study of antimalarial activity of two compounds, i.e. diphenyltin(IV) dibenzoate and triphenyltin(IV) benzoate were performed. The targeted compounds were prepared from their organotin(IV) chlorides via the intermediate products of diphenyltin(IV) dihydroxide and triphenyltin(IV) hydroxide, respectively and reacting the intermediate products with benzoic acid. The antimalarial activity was performed against Plasmodium falcifarum. The results indicate that the triphenyltin(IV) compound is more potent to be used as antimalaria and has potential to be developed as antimalarial drug in the near future.

Item Type:	Conference or Workshop Item (Speech)
Subjects:	Q Science > QD Chemistry
Divisions:	Fakultas Matematika dan Ilmu Pengetahuan Alam (FMIPA) > Prodi Kimia
Depositing User:	Prof. Sutopo Hadi
Date Deposited:	14 Nov 2017 07:53
Last Modified:	14 Nov 2017 07:53
URI:	http://repository.lppm.unila.ac.id/id/eprint/5102

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