Hamzah, Muhammad Syafei (2018) The Relationship Between Transforming Growth Factor-β with Erythema Nodosum Leprosum Recurring Events Based on Immunoglobulin-M Anti Phenolic Glycolipid-1 and Cortisol Muhammad Syafei Hamzah Department of Dermato-venereology Medical Faculty Lampung University, Dr. Abdul Moeloek Hospital Lampung Indonesia. Jounal of Pakistan Association Dermatology, 28 (1). pp. 11-16. ISSN 1560-7650
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Abstract
Background : Erythema Nodosum Leprosum (ENL) recurrent is a serious complication of leprosy immunology, that cause the inflammation of the skin, nerves and other organs. The cause and risk factor of ENL were the immunology complication reaction on leprosy. Some of those were caused by the deposition of the M.Leprae antigen and complex antibody. ENL can cause deformity and disability that make the quality of life decreased. TGF-β and IgM anti PGL- 1 usually increase during recurrent ENL reaction .Objective :This study was to examine the relationship between TGF-β with recurrent ENL based on the IgM anti PGL-1 and Cortisol on leprosy patients in the Dr.H. Abdul Moeloek Hospital Lampung and Dr. Rivai Abdullah Leprosy Hospital Palembang.Subjects : There were 22 subjects leprosy patients with recurrent ENL reactions and 22 subjects unrecurrent reaction as control.Methods : This research examined the subject serum level of TGF-β by ELISA using Human TGF-β Bio legend kit (USA), IgM anti PGL-1 with the Laboratory of Leprosy Institute of Tropical Disease kit, Airlangga University Surabaya, and Cortisol using Stress Xpress Cortisol EIA kit (StressMarq Canada).Results: This research was from 44 subjects of leprosy MB type, there was 22 subjects with recurrent ENL reaction (16 male , 6 female, mean age 34.9 years old) the mean of TGF-β was 62.6.
| Item Type: | Article |
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| Uncontrolled Keywords: | TGF-beta, IgM Anti PGL-1, Cortisol, Recurren ENL |
| Subjects: | R Medicine > RL Dermatology |
| Depositing User: | Dr.dr. Muhammad Syafei Hamzah |
| Date Deposited: | 21 Jul 2022 01:14 |
| Last Modified: | 21 Jul 2022 01:14 |
| URI: | http://repository.lppm.unila.ac.id/id/eprint/43533 |
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