Hadi, Sutopo and Annissa, Annissa and Suhartati, Tati and Yandri, Yandri (2017) Antibacterial Activity of Diphenyltin(IV) and Triphenyltin(IV) 3-Chlorobenzoate Againts Pseudomonas aeruginosa and Bacillus subtilis. Oriental Journal of Chemistry, 33 (3). pp. 1133-1139. ISSN 0970-020 X
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Abstract
In this paper, we reported the syntheses and antibacterial activity test of 2 organotin(IV) compounds, diphenyltin (IV) di-3-chlorobenzoate (2) and triphenyltin (IV) 3-chlorobenzoate (4). These two compounds were prepared by the reaction of diphenyltin (IV) dihydroxide and triphenyltin (IV) hydroxide with 3-chlorobenzoic acid. These compounds were characterized by 1H and 13C NMR, IR, UV-Vis spectroscopies and also based on the microanalytical data. The results of antibacterial activity by diffusion method against Pseudomonas aeruginosa and Bacillus subtilis showed that the triphenyltin(IV) 3-chlorobenzoate was active at concentration of 3.956 x 10-4M (200 ppm), while the chloramphenicol gave inhibition of 6.1894 x 10-4 M (200 ppm), although the halozone was bigger. This result indicated that compound 4 is potentially to be used as antibacterial substance, although the search of other derivative of organotin (IV) with other ligands is still needed to get much higher and much better activity.
| Item Type: | Article |
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| Uncontrolled Keywords: | antibacteria, B. subtilis, organotin(IV) 3-chlorobenzoate, P. aeruginosa |
| Subjects: | Q Science > QA Mathematics Q Science > QD Chemistry |
| Divisions: | Fakultas Matematika dan Ilmu Pengetahuan Alam (FMIPA) > Prodi Kimia |
| Depositing User: | Prof. Sutopo Hadi |
| Date Deposited: | 31 Oct 2017 01:27 |
| Last Modified: | 31 Oct 2017 01:27 |
| URI: | http://repository.lppm.unila.ac.id/id/eprint/4024 |
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