jomori, Takahiro and Setiawan, Andi and sasaoka, miho and Arai, Masayoshi Cytotoxicity of New Diterpene Alkaloids, Ceylonamides G-I, Isolated From Indonesian Marine Sponge of Spongia sp. Sage Publications.
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Abstract
In the course of the search for cancer cell growth inhibitors, 3 new diterpene alkaloids, designated ceylonamides G-I (1-3), together with ceylonamide F (4) were isolated from an Indonesian marine sponge of Spongia sp. The chemical structures of compounds 1-3 were determined using spectroscopic analysis and compared with those of compound 4. Among the isolated compounds, 1 and 4 inhibited the growth of human prostate cancer DU145 cells in a two-dimensional monolayer culture, with an IC50 of 6.9 and 18.8 µM, respectively. Furthermore, these compounds are also effective on spheroid of three-dimensional cell culture model, which was prepared from DU145 cells. Based on the morphological changes in the spheroids, the minimum effective concentrations of compounds 1 and 4 were 10 and 25 µM, respectively.
| Item Type: | Other |
|---|---|
| Subjects: | Q Science > Q Science (General) |
| Depositing User: | Prof Andi Setiawan |
| Date Deposited: | 18 Feb 2022 01:19 |
| Last Modified: | 18 Feb 2022 01:19 |
| URI: | http://repository.lppm.unila.ac.id/id/eprint/39452 |
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