Chen, Shaoyi and Morita, Akihiro and Sukmana, Irza and Maeda, Eijiro and Ohashi, Tohsiro (2015) Development of Fibrin Gel-Microgroove Model For Microvascularization by Endothelial Cells. Bioreheology, 9 (1). pp. 19-23. ISSN 1867-0466 (Print) 1867-0474 (Online)

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Abstract

This study was performed to develop a new for study of microvascularization by endothelial cells (ECs). The effects of the width of microgrooves, initial cell seeding density and a supplementation of vascular endothe lial growth factor (VEGF) on in vitro microvasculaization formed on a polydimethylsiloxane microgroove substrate, were elongated and sprouted within the gel in all the four types of microgrooves. In addition, multicellular network serves as a geometrical constraint for ECs, with a promotional effect on angiogenic responses of ECs, and thus, it can be used as an experimental model in the study of invitro vascularization.

Item Type:	Article
Subjects:	T Technology > TJ Mechanical engineering and machinery
Divisions:	Fakultas Teknik (FT) > Prodi D3 Teknik Mesin
Depositing User:	Dr. IRZA SUKMANA
Date Deposited:	14 Aug 2017 03:07
Last Modified:	14 Aug 2017 03:07
URI:	http://repository.lppm.unila.ac.id/id/eprint/3780

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