Lutfiah, Rosyidatul and Juliasih, Ni Luh Gede Ratna and Hendri, John and Setiawan, Andi
Bioactivity of EtOAc Extract from Mangrove Derived Fungi as Antibacterial
Agent against Staphylococcus aureus and Pseudomonas aeruginosa.
The 2 nd International Conference on Chemistry, Pharmacy and Medical Sciences (ICCPM).
(Unpublished)
Abstract
The increasing cases of resistance of pathogenic bacteria to various types of antibiotics worldwide has
become a serious problem for medicine and human health. Potential diversity of mangrove organisms
as source for new antibacterial compounds against bacterial phatogen. In this study, fungal isolates
were obtained from the mangrove ecosystem in Sriminosari area, Lampung. Fungal isolates were
obtained from mud, roots, stems, and leaves of mangrove with agar diffusion technique. Fungal
cultivation was carried out by the solid-state fermentation method on rice media. The cultivation and co
cultivation results were extracted using ethyl acetate. The bioactivity of the extract was tested against
pathogenic bacteria Pseudomonas aeruginosa and Staphylococcus aureus obtained from hospital
patients. The results of the survey and isolation obtained seventeen isolate. Result of disk diffusion
method showed ethyl acetat extract BA04RF1, BB04RF1, BB05RF1, CB06RF1, CB07RF1 and
CD01RF1 have potential as antibacterial (100g/mL). Futhermore, fungal extract CB07RF1 showed
best antibacterial activity against clinical pathogen S. aureus and P.aeruginosa with inhibition value of
14 and 12 mm respectively. This information is very important as a basis for further research on the
structure and its relationship to activities.
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Bioactivity of EtOAc Extract from Mangrove Derived Fungi as Antibacterial
Agent against Staphylococcus aureus and Pseudomonas aeruginosa. (deposited 29 Nov 2021 01:24)
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