Hadi, Sutopo and samsuar, s and Qudus, Hardoko Insan and Simanjuntak, Wasinton (2021) IN VITRO ANTIBACTERIAL ACTIVITY OF SOME OF DIBUTYLTIN (IV) CHLOROBENZOATE DERIVATIVES AGAINST STAPHYLOCOCCUS AUREUS AND ESCHERICHIA COLI. ARPN Journal of Engineering and Applied Sciences, 16 (15). pp. 1623-1629. ISSN 1819-6608
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Abstract
The antibacterial activity test of some organotin (IV) benzoate derivative compounds, namely dibutyltin (IV) di-o- , m-, p-chlorobenzoate (2-4) against Staphylococcus aureus and Escherichia coli has been performed. These compounds were synthesized from dibutyltin (IV) oxide (1) with o-, m-, p-chlorobenzoic acid. The antibacterial activity tests were conducted by diffusion and dilution method and compared their activity with chloramphenicol as positive control and methanol as negative control. The results of the diffusion test showed that the inhibition zone observed for dibutyltin(IV) oxide was 0 mm indicating that this compound did not have antibacterial activity. The dibutyltin (IV) m-dichlobenzoate with a concentration of 100 ppm was observed to have the biggest inhibition zone against the two bacteria, indicating that compound 3 was the most effective as antibacterial compared to the other series. The results of dilution test showed that the minimum inhibitory concentration (MIC) of dibutyltin (IV) o-dichlorobenzoate against S. aureus and E. coli was 100 ppm while the MIC for dibutyltin (IV) di-m-chlorobenzoate was 40 ppm. The dibutyltin (IV) di-p-chlorobenzoate was only observed against S. aureus with MIC value of 60 ppm. Based on the MIC values obtained in the antibacterial activity of these dibutyltin (IV) di- o-, m-, p-chlorobenzoate indicated that these compounds are potential to be developed as antibacterial drug.
| Item Type: | Article |
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| Uncontrolled Keywords: | antibacterial, in vitro, dibutyltin (IV) dichlorobenzoate, E. coli, MIC, S. aureus. |
| Subjects: | Q Science > QD Chemistry |
| Divisions: | Fakultas Matematika dan Ilmu Pengetahuan Alam (FMIPA) > Prodi Kimia |
| Depositing User: | Prof. Sutopo Hadi |
| Date Deposited: | 29 Sep 2021 09:16 |
| Last Modified: | 29 Sep 2021 09:16 |
| URI: | http://repository.lppm.unila.ac.id/id/eprint/34219 |
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