Hadi, Sutopo and Susantiningsih, Tiwuk and Makkiyah, F.A. and Thadeus, M.S. and Yulianti, R. (2021) Progressive Acute Liver Damage Induced by Repeated 2-Nitropropane: Focused on Obese Mice. Biomedical & Pharmacology Journal, 14 (2). pp. 695-700. ISSN 0974-6242
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Abstract
Obesity is linked to more deaths worldwide. In obesity, there will be a dysregulation of growth signals such as tumorigenesis. Despite the fact that obesity is tend to progress to acute liver damage, not many study using 2-nitropropane (2NP) as a hepatoxicity agent are undertaken especially in obese mice. This study aimed to determine the regime of 2NP that causes acute liver damage. This is an experimental research using a post-test control design group only, with 3 groups of mice ie O1 (obesity), O2+2-NP 1x (induced by 2NP 100 mg/kg BW once), and O2+2-NP 2x (induced by 2NP 100 mg/kg BW twice). At 10 weeks, rats were sacrificed and 100 mg liver tissue were collected for MDA, GSH, MnSOD and CAT enzymes analysis. Analysis statistics were performed by SPSS by one-way Anova and post hoc Tukey. MDA levels of mice were found to be increased in 2NP group than control (3.768 ± 0.407 nmol/ mg) (p < 0,01). Liver GSH, MnSOD and CAT levels of both single injection 2-NP and repeated injection 2-NP groups decreased compared to those of controls (p<0,01). Repeated injection of 2-NP worsen the acute liver damage in obese mice
| Item Type: | Article |
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| Uncontrolled Keywords: | 2-NP, obesity, MDA, GSH, MnSOD, CAT |
| Subjects: | Q Science > QD Chemistry |
| Divisions: | Fakultas Matematika dan Ilmu Pengetahuan Alam (FMIPA) > Prodi Kimia |
| Depositing User: | Prof. Sutopo Hadi |
| Date Deposited: | 12 Aug 2021 06:13 |
| Last Modified: | 12 Aug 2021 06:13 |
| URI: | http://repository.lppm.unila.ac.id/id/eprint/33415 |
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