Hadi, Sutopo and Simanjuntak, Wasinton and Qudus, Hardoko Insan and Yandri, Yandri and Herasari, Dian (2021) In Vitro Antimicrobial Activity Study of Some Organotin(IV) Chlorobenzoates against Staphylococcus aureus and Escherichia coli. Journal of Advanced Pharmacy Education & Research [JAPER], 11 (2). pp. 17-22. ISSN 2249-3379

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Abstract

In vitro antibacterial activity of some organotin(IV) chlorobenzoates including diphenyltin(IV) o-, m-, p-dichlorobenzoate (2, 3, 4) and triphenyltin(IV) o-, m-, p-chlorobenzoate (6, 7, 8) against Staphylococcus aureus and Escherichia coli was studied. The compounds were synthesized by the reaction of diphenyltin(IV) dihydroxide (1) and triphenyltin(IV) hydroxide (5) with o-, m-, p-chlorobenzoic acid in a maximum refluxed time of 4 h using methanol as the solvent of the reaction. The antibacterial activity tests were performed using the diffusion and dilution methods with chloramphenicol and methanol were used as a positive and a negative control, respectively. The antibacterial activity was determined by measuring the diameter of the inhibition zone in each test. The results showed that all compounds synthesized were active against S. aureus, where the largest inhibition zone diameter was observed to be > 16 mm for triphenyltin(IV) o-chlorobenzoate (6) with its smallest concentration of 300 ppm (5.935 x 10-4 M), however, none of the organotin(IV) chlorobenzoates synthesized has activity against E. coli.

Item Type:	Article
Uncontrolled Keywords:	Antibacterial activity, E. coli, Organotin (IV) chlobenzoate, S. aureus
Subjects:	Q Science > QD Chemistry
Divisions:	Fakultas Matematika dan Ilmu Pengetahuan Alam (FMIPA) > Prodi Kimia
Depositing User:	Prof. Sutopo Hadi
Date Deposited:	21 Jun 2021 01:06
Last Modified:	21 Jun 2021 01:06
URI:	http://repository.lppm.unila.ac.id/id/eprint/32702

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