Rani Himayani, Rani and Helmi Ismunandar, Helmi and Aulia Khairunnisa, Aulia and Gayitri Humaera, Gayitri and Meilisa Hidayah Putri, Meilisa and Novi Jayanti, Novi (2021) Effects of SARS-CoV-2 Virus on The Organs. MEDULA, medicalprofession journal of lampung university, 11 (01). pp. 43-47. ISSN 2339-1227

Text 178 Download (68kB)

Abstract

In December 2019, an outbreak of viral pneumonia caused by a novel coronavirus (since named SARS-CoV-2) was identified in Wuhan, China. Within few months, this disease known as coronavirus disease 2019 (COVID-19) spread worldwide, causing a global health emergency. The classic routes for transmission of SARS-CoV-2 are airborne droplets and surface contamination. The clinical presentation of COVID-19 ranges from asymptomatic infection to severe respiratory failure, with fever, fatigue, and cough occurring in most cases. The pathophysiology of SARS-CoV-2 infection is complex, endotoxin and tumor necrosis factor (TNF-α) trigger the production of interleukin (IL)-6 and IL-8, which is followed by a cytokine storm. Moreover, SARS-CoV-2 binds to angiotensin-converting enzyme-2 (ACE2) receptors, which are widely distributed not only in the lung alveolar epithelial cells and nasopharyngeal and oral mucosa but also in the endothelium and vascular smooth muscle cells, in the brain, in the gut, and in peripheral organs such as the liver and kidneys. This suggests that the clinical spectrum of COVID-19 is not limited to local pneumonia, but rather represents a multisystem illness with involvement of different organs and potential for systemic complications.

Item Type:	Article
Subjects:	R Medicine > R Medicine (General)
Divisions:	Fakultas Kedokteran (FK) > Prodi Pendidikan Dokter
Depositing User:	dr. RANI HIMAYANI, Sp.M
Date Deposited:	07 Jun 2021 02:15
Last Modified:	07 Jun 2021 02:15
URI:	http://repository.lppm.unila.ac.id/id/eprint/32145

Actions (login required)

View Item