Putri, Giska Tri and Susianti, Susianti and Bakri, Samsul and Muhartono, Muhartono and Sutyarso, Sutyarso (2020) Identification of Anti-cancer Compounds and Cytotoxic Effects on HeLa Cervical Cancer Cells from Cyperus rotundus L. Growing in Tanggamus, Lampung, Indonesia. In: The 2nd International Conference on Environmental Science, December 2-3, 2020, Universitas Negeri Padang (UNP). (In Press)

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Abstract

This study aims to identify the anti-cancer compounds found in Cyperus rotundus L. tubers originating from Tanggamus, Lampung, Indonesia and then perform a cytotoxic test on Hela cervical cancer cells. The identification of compounds will be carried out using the GC�MS method, while the cytotoxic test will be carried out using the MTT Assay method. There are 142 compounds were detected with thirteen highest compounds, namely d-Selinene (33,02%); Naphthalenone (11,49%); Longiverbenone (2,91%); Caryophyllene oxide (2,78%); 1-Phenanthrenol (2,35%); 1.4,6-Trimethil-1,2,3,3a,4,7,8,8a-octahydro-4,7-ethanoazulene (2,28%); α-Copaene (2,11%); Ylangenal (1,66%); Panaxjapyne A (1,31%); Guaia-1(10),11-diene (1,30%); Ledene oxide-(II) (1,16%); Isospathulenol (1,15%); Methyl-10,12-pentacosadiynoate (1,14%). Various components identified from GC-MS analysis including terpenoids (sesquiterpene hydrocarbons, oxygenated sesquiterpenes and monoterpenes) which are the anticancer bioactive compounds. Cytotoxic test showed that Cyperus rotundus L. tuber extract had a moderate cytotoxic effect (IC50 95,36 µg / ml) on HeLa cervical cancer cells.

Item Type:	Conference or Workshop Item (Paper)
Subjects:	R Medicine > R Medicine (General)
Divisions:	Fakultas Kedokteran (FK) > Prodi Pendidikan Dokter
Depositing User:	Doctor Samsul Bakri
Date Deposited:	25 May 2021 01:35
Last Modified:	25 May 2021 01:35
URI:	http://repository.lppm.unila.ac.id/id/eprint/30653

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