Suhartati, Tati and Yandri, Yandri and Suwandi, Jhons Fatriyadi and Hadi, Sutopo (2010) In vitro and in vivo antiplasmodial activity of oxyresveratrol and artonine isolated from two Artocarpus plants in Indonesia. Oriental Journal of Chemistry, 26 (3). pp. 825-830. ISSN 0970 - 020X, ONLINE ISSN : 2231-5039
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Abstract
ABSTRACT Antiplasmodial activity of two compounds, oxyresveratrol and artonin E isolated from A. dadah and A. rigida, respectively, were evaluated. The in vitro antiplasmodial activity was done on the chloroquine-resistant strain of P. falciparum 3D7, while the in vivo antiplasmodial assay was done on Swiss mice breed which were infected by P. berghei. The two compounds tested showed very high in vitro activity with IC value of 0.05 and 0.2 µg/mL for oxyresveratrol and artonin E, respectively. However, by contrast in the in vivo activity assay, oxyresveratrol has an ED 50 of 10.26 mg/kg, while the artonin E was not able to be determined.
| Item Type: | Article |
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| Subjects: | Q Science > QD Chemistry |
| Divisions: | Fakultas Matematika dan Ilmu Pengetahuan Alam (FMIPA) > Prodi Kimia |
| Depositing User: | Prof. YANDRI AS |
| Date Deposited: | 09 Mar 2021 07:10 |
| Last Modified: | 09 Mar 2021 07:10 |
| URI: | http://repository.lppm.unila.ac.id/id/eprint/28304 |
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