Mumtazah, Dzul Fithria and Listiyaningsih, Erlin and Wijayanti, Nastiti Low PLA2G10 gene expression level tend to make a higher risk of angina pectoris. EJBPS. ISSN 2581-3250 (Submitted)

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Abstract

Angina pectoris is diagnosed by chest pain and considered as one of the symptoms which are triggered by coronary heart disease (CHD). CHD is marked by atherosclerotic plaque formation in the coronary artery and brings on the vascular narrowing which obstructs blood flow. Group IIA and group V of sPLA2 are one of the enzyme groups which play the main role of atherosclerotic plaque formation. On the other hand, group X sPLA2 which is encoded by PLA2G10 has anti-atherogenic properties by inhibits Th1 cell activation in LDLr-/- mice, which is pro-atherogenic. CHD is exacerbated by the presence of risk factors possessed by sufferers. This study aims to examine the proportion of patients with certain metabolic syndromes with their susceptibility to CHD as a cause of angina pectoris linked to PLA2G10 gene expression level. The samples of this research are 133 deposit biological materials from National Cardiovascular Center Harapan Kita’s collection, from angina pectoris patients with a plaque and no plaque in the coroner. The relative quantification of PLA2G10 gene expression shows no difference between the plaque group and no plaque group (p-value = 0,494) which is measured by TaqMan® Gene Expression Assay, but as many as 44% of the group with a plaque and 69% of the group with diabetes mellitus had low levels of PLA2G10 gene expression. The group with risk factors has the greatest percentage having low levels of PLA2G10 gene expression. This indicates that more or less PLA2G10 plays a role in reducing the risk of plaque formation and the severity of risk factors that cause angina pectoris.

Item Type:	Article
Subjects:	Q Science > QL Zoology
Divisions:	Fakultas Matematika dan Ilmu Pengetahuan Alam (FMIPA) > Prodi Magister Ilmu Biologi
Depositing User:	Dzul Fithria Mumtazah
Date Deposited:	07 Dec 2020 01:24
Last Modified:	07 Dec 2020 01:24
URI:	http://repository.lppm.unila.ac.id/id/eprint/27018

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