Yonata, Ade and Ali, Zulkhair and Indrajaya, Taufik and Bahar, Erial and Effendi, Ian and Suhaimi, Novadian and Suprapti, Suprapti (2020) The Association between the Activin A Serum Level and Carotid Intima-Media Thickness in Chronic Kidney Disease Patients. International Journal of Nephrology, 2020. pp. 1-5. ISSN 2090-2158

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Abstract

Introduction. Chronic kidney disease (CKD) is associated with high mortality rates, mainly as a result of cardiovascular complications. Meanwhile, recent studies have suggested a role of a homodimer protein called activin A in chronic kidney disease-mineral and bone disorder (CKD-MBD) conditions that may exist in the vascular calcification and osteolytic process. Ultrasound examination of the carotid intima-media thickness (cIMT) is a noninvasive method to assess vascular calcification. This study aimed to analyze the relationship between the activin A serum level and cIMT in patients with CKD at Mohammad Hoesin Hospital, Palembang, Indonesia. Methods. We conducted a hospital-based, cross-sectional study of consecutive CKD patients at the Department of Internal Medicine, Mohammad Hoesin Hospital, from July to November 2019. The level of activin A was measured by enzyme-linked immunosorbent assay. Meanwhile, cIMT measurements were collected by B-mode ultrasound imaging. Results. A total of 55 patients with CKD were included in this investigation. The median serum activin A level in these patients was 236.17 (116.33–283) pg/mL, while the median cIMT was 0.8 (0.6–1.45) mm. A relationship between the serum activin A level and cIMT (r  =  0.449; ) was observed. During multivariate analysis with linear regression, triglyceride , phosphate , and activin A serum levels were factors associated with cIMT. Conclusion. In this study, a relationship between the activin A serum level and cIMT in patients with CKD was identified. Vascular calcification should be screened for in all CKD patients by the measurement of cIMT.

Item Type:	Article
Subjects:	R Medicine > RC Internal medicine
Divisions:	Fakultas Kedokteran (FK) > Prodi Pendidikan Dokter
Depositing User:	Ade Yonata
Date Deposited:	20 Nov 2020 01:22
Last Modified:	20 Nov 2020 01:22
URI:	http://repository.lppm.unila.ac.id/id/eprint/26387

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• The Association between the Activin A Serum Level and Carotid Intima-Media Thickness in Chronic Kidney Disease Patients. (deposited 20 Nov 2020 01:21)
  • The Association between the Activin A Serum Level and Carotid Intima-Media Thickness in Chronic Kidney Disease Patients. (deposited 20 Nov 2020 01:22) [Currently Displayed]

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