Rizki, Hanriko and Indri, Windarti and Muhartono, Muhartono (2016) IMMUNOEXPRESSION OF ESTROGEN RECEPTORS, PROGESTERONE RECEPTORS AND HER2 IN BREAST CANCER IN BANDAR LAMPUNG. In: Annual Scientific Meeting 2016, Indonesian Association of Pathologists (IAPI), 10-13 Agustus 2016, Batam. (Unpublished)
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Abstract
Background: Breast cancer is the second to cervical cancer that causes deaths in women and about 40,000 deaths expected to occur during 2012 in USA. Currently the most commonly used biomarkers as prognostic and predictive indicators to hormonal therapy and chemotherapy are estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor 2 (HER 2). There is evidence suggest that tumors with negative ER more likely to achieve pathological complete response (pCR) of post neoadjuvant chemotherapy. Some studies states that HER2 overexpression decreases with age. Objective: To determine the expression of ER, PR and HER2 in breast cancer at the Urip Sumoharjo Hospital, Bandar Lampung. Methods: A cross-sectional study by using the immunohistochemistry data in breast cancer patients who were taken from 2014 until 2015. Results and Discussion: From 128 samples tested, the youngest was 25 and the oldest was 71 years old. ER negative in 69 samples (53.9%), 3 samples were positive 1 (2.3%), 6 samples were positive 2 (4.7%) and 50 samples were positive 3 (39.1%). PR negative in 79 samples (61.7%), 6 samples were positive 1 (4.7%), 8 positive samples 2 (6.3%) and 35 samples were positive 3 (27.3%). Her2 negative in 44 samples (34.4%), 2 samples were positive 1 (1.6%), 5 samples were positive 2 (3.9%), and 77 samples were positive 3 (60.2%). In this study, no FISH assessment on Her2 positive 2. Analysis of data on the relationship of age with Her2 not found decreased expression of HER2 with age (P=0,557). Conclusion: HER2 overexpression decreases with age was not found in this study. Keywords: Expression, ER, HER2, PR
| Item Type: | Conference or Workshop Item (Paper) |
|---|---|
| Subjects: | R Medicine > RB Pathology |
| Divisions: | Fakultas Kedokteran (FK) > Prodi Pendidikan Dokter |
| Depositing User: | dr Rizki Hanriko |
| Date Deposited: | 02 Jun 2017 06:52 |
| Last Modified: | 02 Jun 2017 06:52 |
| URI: | http://repository.lppm.unila.ac.id/id/eprint/2370 |
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