Rohmah, wahidatur and Ghaisani, Ulima Mazaya and Mayasari, Diana (2019) Efek Paparan Kronik Pestisida OrganofosfatterhadapSistem Saraf Pusat. AGROMEDICINE UNILA, 6 (2). pp. 388-393. ISSN 2356-332X

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Abstract

Efek Paparan Kronik Pestisida OrganofosfatterhadapSistem Saraf Pusat Wahidatur Rohmah1, Ulima Mazaya Ghaisani1,danDiana Mayasari2 1Program Studi Pendidikan Dokter, Fakultas Kedokteran, Universitas Lampung 2Bagian Ilmu Kedokteran Komunitas,Fakultas Kedokteran, Universitas Lampung Abstrak Prevalensi keracunan pestisida organofosfat di dunia mencapai satu juta kasus per tahunnya. Paparan pestisida oganofosfat memiliki efek toksik terhadap berbagai bagian tubuh manusia sehingga dapat terjadi berbagai macam gangguan, diantaranya terjadi gangguan sistem respirasi, hepatik, kardiovaskular, ketidakseimbangan hormonal, kerusakan ginjal, dan neurologis. Cronic organophosphate-induced neuropsychiatric disorders (COPIND) adalah kumpulan gejala neuropsikiatri akibat paparan kronik organofosfat tanpa gejala kolinergik. Efek toksik pestisida organofosfat yang paling sering muncul antara lain gangguan pada memori, konsentrasi, proses belajar, kecemasan, depresi, gejala psikotik, kelelahan kronik, disfungi otonom, dan gejala ekstrapiramidal seperti distonia dan bradikenesia. Paparan kronik pestisida organosfosfat dapat menyebabkan gangguanfungsi memori berupa memori spasial, memorivisual,maupun memori jangka pendek. Mekanisme utama pada gangguan fungsi memori diduga melibatkan inhibisi asetilkolinesterase, inflamasi sel neuron, dan gangguan transport aksonal. Kata Kunci:organofosfat,pestisida, sistem saraf pusat The Effect of Chronic Exposure of Organophosphate Pesticide OnCentral Nerve System Abstract The number of organophosphate pesticide toxicity reach a million cases each year. The effects of organophosphate pesticide exposure to human body are various including disorder of respiratory, hepatic, cardiovascular, hormonal imbalance, kidney failure, and neurology. Chronic organophosphate-induced neuropsychiatric disorders (COPIND) is a neuropsychiatric syndrome caused by chronic exposure to organophosphate without cholinergic symptoms. Toxic effect of organophosphate are impairment of memory, concentration, learning skill, anxiety, depression, psychotic, chronic exhaustion, autonomic dysfunction, and extrapyramidal symptoms such as dystonia and bradykinesia. Chronic exposure to pesticide organophosphate may lead to memory impairment in the form ofspatial memory, visual memory, and shortterm memory. The main mechanisms in impaired memory function are suspectedly involved the inhibition of asetylcholinesterase,neuron cellinflammation,andimpairment of axonal transport. Key Words:central nerve system, organophosphate,pesticide Korespondensi: Wahidatur Rohmah, alamat Jl. Soemantri Brodjonegoro, e-mail wahidaturr@gmail.com

Item Type:	Article
Subjects:	R Medicine > R Medicine (General)
Divisions:	Fakultas Kedokteran (FK) > Prodi Pendidikan Dokter
Depositing User:	dr. Diana Mayasari
Date Deposited:	05 Jun 2020 09:28
Last Modified:	05 Jun 2020 09:28
URI:	http://repository.lppm.unila.ac.id/id/eprint/21995

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