Dian Isti Angraini, DIA and Arilinia Pratiwi, AP Vitamin C dan Selenium (Se): Pencegah Keracunan Pestisida Organofosfat. AGROMEDICINE UNILA, 5 (1). pp. 503-507. ISSN 2356-332X
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Abstract
Pesticides are chemicals used to eradicate disturbing organisms or pests in agriculture. In Indonesia the inappropriate use of pesticides and chemical fertilizers has become a serious threat among farmers, especially in the health sector. A total of 12,000 deaths per year are reported as a result of pesticide poisoning. Pesticide materials that often cause poisoning is a group of organophosphates and carbamate groups. Organophosphates act as cholinesterase (CheA) inhibitors. Organophosphates effect in inhibiting CheA is irreversible by forming a phosporilated enzyme (enzyme-OP-complex), which stops when there is a slow reactivation of the CheA-OP complex. Selenium is instrumental in reactivating the cholinesterase enzyme through several processes: (1) Activation of cyclic AMP which will eventually activate cholinesterase directly, (2) Balancing NADP and NADPH on aerobic glycolysis pathway in erythrocytes to prevent erythrocytes from damage that can decrease blood cholinesterase production; (3) As antioxidants to protect cells including erythrocytes from damage; (4) As a cofactor for the oxidation process of dealkylation of organophosphate bonds with blood cholinesterase. While vitamin C plays a role in breaking free radicals, simultaneously cleansing toxins (detoxification) of the body with GPX and plays an important role in maintaining Selenium stability in stomach and improve cell function. The addition of Selenium 200 μg and vitamin C 100 mg in farmers at risk of pesticide poisoning will increase 2.14% blood ChEA level.
| Item Type: | Article |
|---|---|
| Subjects: | R Medicine > R Medicine (General) |
| Divisions: | Fakultas Kedokteran (FK) > Prodi Pendidikan Dokter |
| Depositing User: | DIAN ISTI Rini Angraini |
| Date Deposited: | 09 May 2019 05:14 |
| Last Modified: | 09 May 2019 05:14 |
| URI: | http://repository.lppm.unila.ac.id/id/eprint/12218 |
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