Arai, Masayoshi and Kamiya, Kentaro and Shin, Dayoung and Matsumoto, Hirokazu and Hisa, Tomoya and Setiawan, Andi and Kotoku, Naoyuki and Kobayashi, Motomasa (2016) N-Methylniphatyne A, a New 3-Alkylpyridine Alkaloid as an Inhibitor of the Cancer Cells Adapted to Nutrient Starvation, from an Indonesian Marine Sponge of Xestospongia sp. Chemical and Pharmaceutical Bulletin, 64 (7). pp. 766-771. ISSN 1347-5223


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In the course of searching for selective growth inhibitors of the cancer cells adapted to nutrient starvation, a new 3-alkylpyridine alkaloid named N-methylniphatyne A (1) was isolated from an Indonesian marine sponge of Xestospongia sp. The chemical structure of 1 was determined on the basis of the spectroscopic analysis and comparison with the synthesized 1 and its analogues. Compound 1 showed the cytotoxic activity against PANC-1 cells under the condition of glucose starvation with IC50 value of 16 μM, whereas no growth inhibition was observed up to 100 μM under the general culture conditions.

Item Type: Article
Additional Information: # These authors contributed equally to this work.
Subjects: Q Science > QD Chemistry
Divisions: Fakultas Matematika dan Ilmu Pengetahuan Alam (FMIPA) > Prodi Kimia
Depositing User: Dr. Andi Setiawan
Date Deposited: 25 Jun 2018 02:22
Last Modified: 25 Jun 2018 02:22

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