Fajarwati, Annisa Elcentia and Bahri, Syaiful and Lutfiah, Rosyidatul and Setiawan, Andi Anti-biofilm Activity of EtOAc Extract from Indonesian Mangrove-Derived Fungi against Staphylococcus aureus. Journal of Tropical Life Science. ISSN 19853718, 19858345, 21804249 (Submitted)

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Abstract

The abundance of natural resources in coastal areas offers huge poten-tial for the discovery of medicinal compounds. Because mangrove has the ability to grow in challenging ecosystems, it is reasonable to expect mangrove-derived fungi with diverse potential as drugs. Mangrove-derived fungi are still unexplored as a source of bioactive metabolites that are important in developing biopharmaceuticals. This study aimed to screen ethyl acetate extract from fungi associated with mud and mangrove plants as a source of anti-biofilm agents. In this study, eight isolates of fungi associated with mangroves fermented on selective me-dia of shrimp shell waste and the EtOAc extract were tested against S. aureus bacteria. Compounds that have anti-biofilm activity can be ob-served by staining with crystal violet and measuring their optical density (OD) at 630 nm. The results showed that isolates 20AA03RF, 20BA04RF, 20BB04RF, 20BA0502RF, 20BB0501RF, 20CD01RF, 20CL0102RF, and 20CL02RF had inhibitory activity against biofilm formation at a concentration 250 µg/mL. The 20CD01RF isolate had the greatest biofilm inhibitory activity compared to other samples and was selected for further research. The results of this study are important to be used as the main information for further research in the search for anti-biofilm agent compounds.

Item Type: Article
Subjects: Q Science > Q Science (General)
Depositing User: Dr. Andi Setiawan
Date Deposited: 06 Jan 2022 01:13
Last Modified: 06 Jan 2022 01:13
URI: http://repository.lppm.unila.ac.id/id/eprint/37618

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