Noviany, Noviany and Setiawan, Andi and Hadi, Sutopo and Irawan, Bambang (2019) Suplemen (Syarat Tambahan) Pengajuan Guru Besar: Hibah Penelitian Kerja Sama Internasional (PKSI) 2019 dari BLU-Unila. BLU-Unila. (Unpublished)

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Abstract

Infectious diseases caused by bacteria has become the global health issues especially antibacterial drug resistance. The most serious concern with antibacterial resistance is that some bacteria have become resistant to almost all antibacterial drugs and making them less effective. Overusing or misusing of these drugs can make resistance develop even faster. Various efforts have been made by many researchers to find antibacterial drugs including through chemical constituent studies from natural plants. Plants are the one of the most important natural resources because they are relatively safe from the side effects and cheap. One of the potential plants that has antibacterial properties is the jengkol plant (Archidendron jiringa (Jack) I. C. Nielsen). Jengkol plant is the one of Lampung's natural resources that has not been optimally used, and its utilization is in line with Unila's superior research focus in the field of technology development and drug health. In this research, a chemical constituents study of roots and stem barks of jengkol plants have been carried out through several stages including isolation, purification, identification, and biological activity evaluation. The stages of isolation of secondary metabolites were carried out by extraction technique followed by fractionation using chromatographic methods such as vacuum liquid chromatography (VLC), and column chromatography (CC). Meanwhile, characterization and identification of the active fraction was carried out by proton Nuclear Magnetic Resonance (1H-NMR). The pure compounds will be tested for their biological activity against grams positive Bacillus subtilis and negative bacteria Escherichia coli using the agar disc diffusion and dilution method. The research outputs obtained has been prepared as a draft manuscript that ready to submit to international reputable scientific journals such as the Brazillian Journal of Pharmacognosy (International, Elsevier, IF: 1.754, Q2) or Pharmaceutical Biology (International, Q2 Scimago, Scopus indexed).

Item Type:	Other
Subjects:	Q Science > QD Chemistry
Divisions:	Fakultas Matematika dan Ilmu Pengetahuan Alam (FMIPA) > Prodi Kimia
Depositing User:	Dr Noviany
Date Deposited:	13 Dec 2021 09:38
Last Modified:	13 Dec 2021 09:38
URI:	http://repository.lppm.unila.ac.id/id/eprint/37275

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