Devi Nur Anisa, Anisa and Ilim, Ilim and Chairil Anwar, Anwar and Endang Astuti, Astuti Synthesis of Curcumin Analogs Under Ultrasound Irradiation. In: 3RD INTERNATIONAL CONFERENCE ON APPLIED SCIENCE MATHEMATICS AND INFORMATICS (3RD ICASMI), 3-4 september 2020, FMIPA Universitas Lampung. (Unpublished)

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Curcumin is a secondary metabolite compound which is known to have important biological activities, such as antibacterial, anticancer, antioxidant, antidiabetic and anti-inflammatory properties. In this research, synthesis of curcumin analog compound based on veratraldehyde has been performed. The synthesis stage involves the Claisen-Schimdt condensation of veratraldehyde and cyclopentanone using a base catalyst (KOH) in ethanol as a solvent and performed by ultrasound method for 15 minutes, producing a curcumin analogue compound ((2E, 5E) -2,5-bis (3,4-dimethoxibenzylidine) ) cyclopentanon). The results of these compounds were analyzed using DI-MS, and FTIR spectra. The results showed that 15.4 mmol veratraldehyde synthesized with 7 mmol cyclopentanone using a base catalyst (KOH) in ethanol solvent resulted in a yield of 85.71% and a molecular weight of 380 g/mol. The results of the synthesis of curcumin analog compounds from the ultrasound method are yellow solids with a melting point of 194 °C.

Item Type: Conference or Workshop Item (Lecture)
Subjects: Q Science > QD Chemistry
Divisions: Fakultas Matematika dan Ilmu Pengetahuan Alam (FMIPA) > Prodi Kimia
Depositing User: Devi Nur Anisa
Date Deposited: 12 Nov 2020 02:18
Last Modified: 12 Nov 2020 02:18

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