Hadi, Sutopo and Noviany, Noviany and Rilyanti, Mita (2018) IN VITRO ANTIMALARIAL ACTIVITY OF SOME ORGANOTIN(IV)2-NITROBENZOATE COMPOUNDS AGAINST PLASMODIUM FALCIPARUM. Macedonian Journal of Chemistry and Chemical Engineering, 37 (2). ISSN 1857-5552 (In Press)
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Abstract
Antimalarial activity study of organotin(IV) derivatives with nitrobenzoic acid derivatives used as ligands has been performed. The targeted compounds were prepared from their organotin(IV) chlorides via dibutyltin(IV) oxide, diphenyltin(IV) dihydroxide, and triphenyltin(IV) hydroxide intermediate prod-ucts, followed by reacting the intermediate products with 2-nitrobenzoic acid. The antimalarial activity was performed against P. falciparum. The results showed that the IC50 values of dibutyiltin(IV) di-2-nitrobenzoate, diphenyltin(IV) di-2-nitrobenzoate, and triphenyltin(IV) 2-nitrobenzoate were in 8.4 × 10-3, 5.3 × 10–2, and 9.1 × 10–3 μg/ml, respectively. The IC50 values were slightly higher than the value for chloroquine (2 × 10–3 μg/ml) used as the positive control; however, one advantage is that all prepared organotin(IV) compounds were not resistant to Plasmodium, making the use of organotin(IV) as an anti-malarial is possible. The results indicated that the derivative of triphenyltin(IV) was more potent when used as an antimalarial, as expected, and has potential to be developed as an antimalarial drug in the fu-ture.
| Item Type: | Article |
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| Uncontrolled Keywords: | antimalarial activity, IC50, organotin(IV) nitrobenzoate, P. falciparum |
| Subjects: | Q Science > QD Chemistry |
| Divisions: | Fakultas Matematika dan Ilmu Pengetahuan Alam (FMIPA) > Prodi Kimia |
| Depositing User: | Prof. Sutopo Hadi |
| Date Deposited: | 15 Nov 2018 03:05 |
| Last Modified: | 15 Nov 2018 03:05 |
| URI: | http://repository.lppm.unila.ac.id/id/eprint/9953 |
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