., Muhartono and N. D, Larasati and Hanriko, Rizki and ., Sutyarso (2013) The Protective Effect of Honey on Ethanol-Induced Liver Injury in Rats. MKB, 45 (1).


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Abstract Honey is one of the honeybee’s’ products which are often used as medicine since a long time ago. Honey has a high antioxidant activity, but studies to investigate its protective effect on ethanol-induced liver injury have not been carried out in Indonesia. The aim of this study was to investigate the protective effect of honey on ethanol-induced rat liver injury. This study done conducted in the Pharmacology and Pathology laboratory in November 2011. This experimental laboratory study used randomized complete design on 25 rats divided into five groups. Group 1: control; group 2: ethanol; group 3, 4 and 5: honey + ethanol. Ethanol 0.01 mL/g body weight was given orally to group 2, 3, 4 and 5 for 14 days. Honey + ethanol groups were given honey at a dose of 0.0018 mL/g body weight, 0.0054 mL/g body weight, and 0.016 mL/g body weight orally at 1.5 hours prior to ethanol administration. Liver samples were taken for histopathological examination. The parameter of liver injury was fatty degeneration. The results showed that ethanol induced fatty degeneration compared to control group. Group 3, 4 and 5 showed significantly decreased fatty degeneration (p<0.050, p <0.001, p <0.001). The improvement was prominent in group 5. In conclusion, honey has a protective effect on rat liver injury. [MKB. 2013;45(1):16–22] Key words: Ethanol, fatty degeneration, honey

Item Type: Article
Subjects: A General Works > AC Collections. Series. Collected works
A General Works > AI Indexes (General)
Divisions: Fakultas Kedokteran (FK) > Prodi Pendidikan Dokter
Depositing User: Daud . Busrani
Date Deposited: 01 Jul 2016 02:12
Last Modified: 01 Jul 2016 02:12
URI: http://repository.lppm.unila.ac.id/id/eprint/94

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