mustofa, syazili and Kurniawaty, Evi and Rahmanisa, Soraya (2018) THE EFFECT OF MANGROVE (Rhizophora apiculata) BARK EXTRACT ETHANOL ON HISTOPATHOLOGY PANCREAS OF MALE WHITE RATS SPRAGUE DAWLEY STRAIN EXPOSED TO CIGARETTE SMOKE. Acta Biochimica Indonesiana, 1 (1). pp. 7-13.

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Cigarette smoke is free radical that causing some pathological conditions such as inflammation, proteolysis, and oxidative stress. In previous studies, mangrove (Rhizophora apiculata) bark extract showed the potential effect as an antioxidant. Mangrove and mangrove associates are abundant plants that grow throughout Indonesian shorelines that have high pharmaceutical and food values. Objective: The purpose of this study is to explore the potential of Rhizophora apiculata bark extract in protecting pancreas of male white rat (Rattus novergicus) Sprague Dawley strain exposed to cigarette smoke. Methods: This research was an experimental study using a posttest-only control group design. Mangrove bark was extracted by using the maceration method. Cigarette smoke exposure was performed using an electric cigarette. Liver inflammation is assessed histopathologically. Results: Significant results (p <0.05) were found between the control and cigarette groups as well as the cigarette and bark extract + control groups. The results were not significant (p> 0.05) between the control and the bark extract + cigarette. Conclusion : The administration of mangrove bark extract has a potential to protect the damage of pancreatic male white rats (Rattus norvegicus) Sprague Dawley strains exposed to cigarette smoke.

Item Type: Article
Subjects: R Medicine > RM Therapeutics. Pharmacology
Divisions: Fakultas Kedokteran (FK) > Prodi Pendidikan Dokter
Date Deposited: 30 Oct 2018 03:12
Last Modified: 30 Oct 2018 03:12

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