Nurcahyani, Nuning and Busman, Hendri and Sutyarso, Sutyarso and Rahmawati, Dwi Pratami and Kanedi, Mohammad (2018) Antispermatogenic Effect of Seeds Extract of Papaya (Carica papaya L.) in Mice. The Pharmaceutical and Chemical Journal, 5 (4). pp. 18-22. ISSN 2349-7092

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To enrich new evidence about the anti-fertility activity of seeds extract of papaya (Carica papaya L.) in test animals, especially mice. Male mice (n=20) were grouped into four. The first group received only distilled water containing 1% CMC as the control. Group 2, 3 and 4 consecutively received papaya seeds extract of 2, 4 and 8 mg/40 g body weight. All treatment administered orally using stomach sonde once daily for 35 days. Study parameters assessed were the number spermatogonia, spermatocyte and spermatid cell counts, diameter and epithelial thickness of seminiferous tubules of the testis. There is no significant different in the number of spermatogonia between treatment groups. Spermatocyte and spermatid cells significantly decreased by the extract, especially at the highest dose. Additionally, the diameter and epithelial thickness of seminiferous tubules of testis are siginicantly reduced by the extract at the dose of 8 mg/40g body weight. Papaya seeds extract as potential to be used as anti fertility agent. Keywords: Carica papaya, contraceptives, papaya seeds, antispematogenic, antifertility

Item Type: Article
Subjects: Q Science > QL Zoology
Divisions: Fakultas Matematika dan Ilmu Pengetahuan Alam (FMIPA) > Prodi Biologi
Depositing User: M.Biomed. Hendri Busman
Date Deposited: 26 Oct 2018 10:15
Last Modified: 26 Oct 2018 10:15

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