Suhartati, Tati and Hernawan, Hernawan and Suwandi, Jhons Fatriyadi and Yandri, Yandri and Hadi, Sutopo (2018) ISOLATION OF ARTONIN E FROM THE ROOT BARK OF ARTOCARPUS RIGIDA, SYNTHESIS OF ARTONIN E ACETATE AND EVALUATION OF ANTICANCER ACTIVITY. Macedonian Journal of Chemistry and Chemical Engineering, 37 (1). pp. 35-42. ISSN 1857-5552

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Abstract

Artonin E was isolated from the root bark of A. rigida. The isolated compound was then esterified using a known procedure by the addition of acetic anhydride with pyridine catalyst. The structure of the synthesized compound was carefully determined by physical and spectroscopic techniques and compared to the data in the literature. The anticancer activity test against murine leukemia cancer cells P-388 showed that the ester compound has good activity with an IC50 of 2.79 μg/ml and much better stability during storage compared to artonin E itself.

Item Type: Article
Uncontrolled Keywords: A. rigida; artonin E acetate; esterification; anticancer activity
Subjects: Q Science > QD Chemistry
Divisions: Fakultas Matematika dan Ilmu Pengetahuan Alam (FMIPA) > Prodi Kimia
Depositing User: Prof. Sutopo Hadi
Date Deposited: 28 Jun 2018 08:17
Last Modified: 28 Jun 2018 08:17
URI: http://repository.lppm.unila.ac.id/id/eprint/8182

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