Sugiarti, Septilia and Ramadhian, Muhammad Ricky and Carolia, Novita (2018) Vitamin D sebagai Suplemen dalam Terapi Tuberkulosis Paru. Majority, 7 (2). pp. 198-202. ISSN 2337-3776


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Abstract Tuberculosis (TB) is a communicable disease caused by Mycobacterium tuberculosis. In 1992, World Health Organization (WHO) stated tuberculosis as Global Emergency. In 2013 WHO’s report there are approximately 8,6 million TB cases, 450.000 people under MDR-TB, and 170.000 people deceased. Regions with the largest number of pulmonary tuberculosis are Africa 37%, South East Asia 28%, and East Mediteranian 17%. In Indonesia, pulmonary TB prevalence categorized by three regions, Sumatra (33%), Java and Bali (23%), and Eastern Indonesia (44%). Experts try solving it to decrease morbidity and mortality caused by tuberculosis, also increasing of MDR-TB (Multi Drugs Resistance Tuberculosis) incidence. Vitamin D is known good for bone health, but it also works as immunomodulator to counter against bacterias, includes Mycobacterium tuberculosis. Some studies indicated that vitamin D deficiency is common as TB risk factor. 1,25-dihydroxy vitamin D is an active metabolite of vitamin D that induce antimycobacterial activity in macrophages to upregulate protective innate host responses through a peptide called cathelicidin. A study showed vitamin D supplementation give significance improvement in clinical finding. Vitamin D as supportive therapy which given with anti-tuberculosis drugs in addition to improve clinical finding, could be a suitable suggestion as prophylaxis in TB household contacts that easy to afford.

Item Type: Article
Subjects: R Medicine > R Medicine (General)
R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine
R Medicine > RM Therapeutics. Pharmacology
Divisions: Fakultas Kedokteran (FK) > Prodi Pendidikan Dokter
Depositing User: MSc Muhammad Ricky Ramadhian
Date Deposited: 21 Jun 2018 02:13
Last Modified: 21 Jun 2018 02:13

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