Nurdin, Samsu Udayana and Sukohar, Asep (2017) Antiglucosidase and Antioxidant Activities of Ginger, Cinnamon, Turmeric and Their Combination. International Journal of Pharmacy and Pharmaceutical Research, 10 (1). pp. 296-306. ISSN 23497203

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Abstract

Background and Objective: Number of diabetic patients in Indonesia is expected to be 21.3% in 2030. Some traditional medicines have been using crude plant extracts for diabetes managements. Combination of extracts may have more complex effect on diabetes due to the interaction occurred among the individual components. The study aimed to evaluate the effect of combination of ginger, cinnamon and turmeric on anti-glucosidase and antioxidant activities. Material and Methods: The α-glucosidase inhibitory activity and antioxidant were measured by α-glucosidase inhibitory and α, α-diphenylẞ-dipicryl-hydrazyl (DPPH) free radical scavenging assay, respectively. The total phenolic content of the extracts was determined by folin ciocaletus reagent method. The IC50 value of the most potential extract was calculated. Observation, findings, and Conclusion: Turmeric extract was the most potent to inhibit alpha-glucosidase followed by extracts of ginger and cinnamon. Turmeric extract inhibited α-glucosidase by 68.44 % followed by extracts of ginger and cinnamon, 22.46% and 19.613% respectively. The potentiality of the extracts to sequence free radical was not in concomitant with their antiglucosidase activities as cinnamon sequenced 82.6% free radicals, was higher than ginger and turmeric (79.75% and 79.53%, respectively). Combination of the extracts did not exert synergetic or antagonistic effect on anti-glucosidase activity. Cinnamon extract has the highest ability to neutralize the free radical, followed by ginger and turmeric extracts and mixing of the extracts increase antioxidant activities. Extract containing higher total phenolic compound tend to have higher antioxidant activity but less effective to inhibit alpha glucosidase enzyme activity.

Item Type: Article
Subjects: S Agriculture > S Agriculture (General)
Divisions: Fakultas Pertanian (FP) > Prodi Teknologi Hasil Pertanian
Depositing User: SAMSU UDAY
Date Deposited: 16 Nov 2017 04:48
Last Modified: 16 Nov 2017 04:48
URI: http://repository.lppm.unila.ac.id/id/eprint/5456

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