Hernawan, Hernawan and Suhartati, Tati and Yandri, Yandri and Suwandi, Jhons Fatriyadi (2017) ISOLATION, CHARACTERIZATION, MODIFICATION, AND BIOACTIVITY TEST OF ARTONIN E FROM ROOT BARKS OF Kenangkan (Artocarpus rigida). In: Inetrnational Confrence on Applied Sciences Mathematics and Informatics, July, 13 - 15, 2017, Bandar Lampung, Indonesia. (Unpublished)

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Abstract

Diarrheal disease is an endemic in Indonesia and it is a potential illness of Extraordinary Occurrence which is often followed by death. Several organic compounds have been isolated from natural products which are common used as drugs. Artocarpus rigida or Kenangkan is one of natural products that contains flavonoid as derivate compounds. Flavonoid is known as a good antibacterial agent. The research phases were conducted following; preparation, extraction, isolation, purification, identification, modification, and antibacterial test. The isolated flavonoid was obtained from semipolar fraction from root barks of Kenangkan and visualized by TLC. Purification process was used VLC method. The molecular structure of the compound was determined by physical and spectroscopic data (UV-Vis and IR). The obtained compound was 1.6 g Artonin E has a yellow solid with melting point 250-252oC, mean while a modified artonin E with acetic anhydride has a white solid with melting point 192-194oC. The result of bioactivity test, an isolated artonin E has better antibacterial activity than a modified artonin E towards Bacillus subtilis, but the activities are not included in a high category.

Item Type: Conference or Workshop Item (Paper)
Subjects: Q Science > QD Chemistry
Divisions: Fakultas Matematika dan Ilmu Pengetahuan Alam (FMIPA) > Prodi Kimia
Depositing User: Prof. Tati Suhartati
Date Deposited: 15 Nov 2017 07:24
Last Modified: 15 Nov 2017 07:24
URI: http://repository.lppm.unila.ac.id/id/eprint/5304

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