Berawi, Khairun Nisa Synthesis, characterization and in vitro activity study of some organotin(IV) carboxylates against leukemia cancer cell, L-1210. De Gruyter.
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Abstract
Abstract: This paper presents successful resynthesizing of several dibutyl-, diphenyl-, and triphenyltin(IV) carboxylate compounds, and their activity against leukemia cancer cell, L-1210. The compounds were synthesized by reacting the dibutyltin(IV) oxide (DBTO) (1), diphenyltin(IV) oxide (DPTO) (3), and triphenyltin(IV) hydroxide (TPTOH) (5) with 3-hydroxybenzoic acid (3-HHBz). Prior to cancer activity tests, the compounds were characterized by UV–Vis, FT-IR, NMR (both 1 H NMR and 13 C NMR), and microanalysis to determine elemental composition of the samples. The anticancer tests revealed that triphenyltin(IV) 3-hydroxybenzoate (TPTHBz) (6) displayed significantly higher activity than those exhibited by dibutyltin(IV) di(3-hydroxybenzoate) (DBTHBz) (2) and diphe- nyltin(IV) di(3-hydroxybenzoate) (DPTHBz) (4).
| Item Type: | Article |
|---|---|
| Subjects: | R Medicine > R Medicine (General) |
| Divisions: | Fakultas Kedokteran (FK) > Prodi Pendidikan Dokter |
| Depositing User: | KHAIRUN NI NISA BERAWI |
| Date Deposited: | 04 Sep 2023 01:39 |
| Last Modified: | 04 Sep 2023 01:39 |
| URI: | http://repository.lppm.unila.ac.id/id/eprint/52444 |
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