Hadi, Sutopo (2017) The Antimalaria Activity of Some Organotin(IV) Carboxyilate against Plasmodiun falcifarum. In: The 3rd International Symposium on Current Progress in Mathematics and Sciences 2017, July 26-27, 2017, Bali.

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Abstract

Organotin(IV) carboxylate and its derivatives have been known to have strong biological activity even at very low concentration making these compounds continue to attract more attention to be explored [1-6]. Continuing our success in the syntheses and activity studies of some organotin(IV) carboxylates in the previous research [4-6], in this paper, we reported the initial study of antimalaria activity study of three organotin(IV) derivatives. The targeted compounds were prepared from their organotin(IV) chlorides via the intermediate products of dibutyltin(IV) oxide, diphenyltin(IV) dihydroxide and triphenyltin(IV) hydroxide, respectively and reacting the intermediate products with 2-chlorobenzoic acid. The antimalaria activity was performed against Plasmodium falcifarum. The results suggest that the triphenyltin(IV) compound is more potent to be used as antimalaria and has potential to be developed as antimalarial drug in the near future. Keywords: antimalaria, inhibition concentration, organotin(IV) carboxylates, P. Falcifarum References 1. R.B. Rastogi, M.M. Singh, K. Singh and M. Yadav, Port. Electrochim. Acta, 2005, 22, 315. 2. S. Hadi., H. Afriyani, W.D. Anggraini, H.I. Qudus, T. Suhartati. Asian J. Chem., 2015, 27, 1509. 3. W. Rehman, A. Badshah, S. Khan and L.T.A. Tuyet, Eur. J. Med. Chem., 2009, 44, 3981. 4. S. Hadi and M. Rilyanti, Oriental J. Chem., 2010, 26, 775. 5. S. Hadi, B. Irawan and Efri, J. Appl. Sci. Res., 2008, 4, 521. 6. S. Hadi, M. Rilyanti and Nurhasanah, Modern Appl. Sci., 2009, 3, 12.

Item Type: Conference or Workshop Item (Speech)
Subjects: Q Science > QD Chemistry
Divisions: Fakultas Matematika dan Ilmu Pengetahuan Alam (FMIPA) > Prodi Kimia
Depositing User: Prof. Sutopo Hadi
Date Deposited: 10 Nov 2017 14:38
Last Modified: 10 Nov 2017 14:38
URI: http://repository.lppm.unila.ac.id/id/eprint/5154

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