Hadi, Sutopo (2017) The in vitro Antimalaria Activity of Some Organotin(IV) nitrobenzoate compounds against Plasmodium falcifarum. In: EastWest Chemistry Conference 2017, October 12-14, 2017, Skopje Macedonia.

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Abstract

Organotin(IV) carboxylate and its derivatives have been known to have strong biological activity even at very low concentration making these compounds continue to attract more attention to be explored [1-6]. Continuing our success in the syntheses and activity studies of some organotin(IV) carboxylates in the previous research [4-6], in this paper, we reported the initial study of antimalaria activity study of three organotin(IV) derivatives. The targeted compounds were prepared from their organotin(IV) chlorides via the intermediate products of dibutyltin(IV) oxide, diphenyltin(IV) dihydroxide and triphenyltin(IV) hydroxide, respectively and reacting the intermediate products with 2-chlorobenzoic acid. The antimalaria activity was performed against Plasmodium falcifarum. The results suggest that the triphenyltin(IV) compound is more potent to be used as antimalaria and has potential to be developed as antimalarial drug in the near future.

Item Type:	Conference or Workshop Item (Speech)
Subjects:	Q Science > QD Chemistry
Divisions:	Fakultas Matematika dan Ilmu Pengetahuan Alam (FMIPA) > Prodi Kimia
Depositing User:	Prof. Sutopo Hadi
Date Deposited:	14 Nov 2017 07:53
Last Modified:	14 Nov 2017 07:53
URI:	http://repository.lppm.unila.ac.id/id/eprint/5107

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