Tati, Suhartati and Nurul Fatimah, Nurul and Yandri, Yandri and Rahmat Kurniawan, Rahmat and Syaiful, Bahri and Sutopo, Hadi (2021) The Anticancer, Antimalarial, and Antibacterial Activities of Moracalkon a Isolated from Artocarpus kemando Miq. Journal of Advanced Pharmacy Education & Research, 11 (4). pp. 105-110. ISSN E-ISSN: 2249-3379

Preview

Text The Anticancer, Antimalarial, and Antibacterial Activities of Moracalkon a Isolated from Artocarpus kemando Miq.pdf Download (376kB) | Preview

Abstract

Artocarpus kemando Miq. (pudau) is a species of plant from the genus Artocarpus, family Moraceae. Some compounds have previously been isolated from the genus Artocarpus and they showed some bioactivities as antimicrobial, anticancer, antifungal, antiplatelet, antiinflammatory, antioxidant, antidiabetic and cytotoxic properties. This study aims to isolate and characterize the flavonoid compounds in the root wood of the pudau plant (A. kemando Miq.) which was obtained from Karang Anyar, Klaten, Penengahan, South Lampung, Indonesia. A chalcone compound namely moracalkon A (1) is succesfullyisolated from the root wood of the pudau plant, A. kemando Miq.. Compound 1 was obtained as a yellow solid with a melting point range of 122-125oC. It was well characterized with spectroscopy techniques of UV-Vis, IR, and NMR, and its anticancer activity was tested using murine leukemia cells P-388 and IC50 value was 1.54 g/mL. The antimalarial activity test against Plasmodium falciparum gave IC50 value of 0.08 g/mL and it is categorized as a very active. Furthermore, the antibacterial activity test towards Bacillus subtilis and Escherichia coli showed that compound 1 was strong.

Item Type:	Article
Subjects:	Q Science > QD Chemistry
Divisions:	Fakultas Matematika dan Ilmu Pengetahuan Alam (FMIPA) > Prodi Kimia
Depositing User:	Syaiful Bahri
Date Deposited:	30 Jan 2023 01:47
Last Modified:	30 Jan 2023 01:47
URI:	http://repository.lppm.unila.ac.id/id/eprint/48156

Actions (login required)

View Item