Hendri, Busman and Sutyarso, Sutyarso and Salman, Farisi and fukrapti, fukrapti and Aulia, Rika Fahrumnisa (2022) Turmeric Rhizome’s Extract Reduce Epithelium Cells and Endometrium Layer Thickness of Female Rats. Biomedical & Pharmacology Journal, 15 (1). pp. 299-304. ISSN 2456–2610

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Abstract

Turmeric rhizome extract has been shown to have ntifertility effects as antiestrogenic and is reversible. This study aims to rate turmeric rhizome extract (Curcuma longa L.) antiestrogenic potential towards epithelium cell and ndometrium layer thickness reduction on female rats. Twenty-eight female rats aged around 6-8 weeks old and weighing around 200-250 g were divided into four groups using a completely randomized design. The control group received only aquadest. Treatment groups 1, 2, and 3 received 250, 500, and 1.000 mg/kg BW turmeric rhizome extract, espectively, for five days. At the end of the examination, there was a significant decrease in the number of endometrial epithelial cells in the turmeric group (p=0,000), in line with the increase in the dose given. This research also shows the presence of antiestrogenic potential effects associated with an endometrium layer thickness (p=0.013), and there was a decrease in endometrium thickness associated between the control group and treatment group (p<0,05). Conclusions: Turmeric rhizome extract has an antiestrogenic potential and can reduce the total of epithelium cells and endometrium layer thickness on female rats.

Item Type: Article
Subjects: Q Science > Q Science (General)
Q Science > QK Botany
Divisions: Fakultas Matematika dan Ilmu Pengetahuan Alam (FMIPA) > Prodi Magister Ilmu Biologi
Depositing User: M.Biomed. Hendri Busman
Date Deposited: 19 May 2022 06:42
Last Modified: 19 May 2022 06:42
URI: http://repository.lppm.unila.ac.id/id/eprint/41686

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