Annissa, Annissa and Suhartati, Tati and Yandri, Yandri (2017) Antibacterial Activity of Diphenyltin(IV) and Triphenyltin(IV) 3-Chlorobenzoate Againts Pseudomonas aeruginosa and Bacillus subtilis. Oriental Journal of Chemistry, 33 (3). pp. 1133-1139. ISSN 0970-020 X


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In this paper, we reported the syntheses and antibacterial activity test of 2 organotin(IV) compounds, diphenyltin (IV) di-3-chlorobenzoate (2) and triphenyltin (IV) 3-chlorobenzoate (4). These two compounds were prepared by the reaction of diphenyltin (IV) dihydroxide and triphenyltin (IV) hydroxide with 3-chlorobenzoic acid. These compounds were characterized by 1H and 13C NMR, IR, UV-Vis spectroscopies and also based on the microanalytical data. The results of antibacterial activity by diffusion method against Pseudomonas aeruginosa and Bacillus subtilis showed that the triphenyltin(IV) 3-chlorobenzoate was active at concentration of 3.956 x 10-4M (200 ppm), while the chloramphenicol gave inhibition of 6.1894 x 10-4 M (200 ppm), although the halozone was bigger. This result indicated that compound 4 is potentially to be used as antibacterial substance, although the search of other derivative of organotin (IV) with other ligands is still needed to get much higher and much better activity.

Item Type: Article
Uncontrolled Keywords: antibacteria, B. subtilis, organotin(IV) 3-chlorobenzoate, P. aeruginosa
Subjects: Q Science > QD Chemistry
Divisions: Fakultas Matematika dan Ilmu Pengetahuan Alam (FMIPA) > Prodi Kimia
Depositing User: Prof. Sutopo Hadi
Date Deposited: 31 Oct 2017 01:27
Last Modified: 31 Oct 2017 01:27

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