Arai, Masayoshi and Kamiya, Kentaro and Shin, Dayoung and Matsumoto, Hirokazu and Hisa, Tomoya and Setiawan, Andi and Kotoku, Naoyuki and Kobayashi, Motomasa N-Methylniphatyne A, a New 3-Alkylpyridine Alkaloid as an Inhibitor of the Cancer Cells Adapted to Nutrient Starvation, from an Indonesian Marine Sponge of Xestospongia sp. The Pharmaceutical Society of Japan.

[img] Text
18% - Jurnal 2016-1.pdf - Masayoshi Arai.pdf

Download (1MB)

Abstract

n the course of searching for selective growth inhibitors of the cancer cells adapted to nutrient starva�tion, a new 3-alkylpyridine alkaloid named N-methylniphatyne A (1) was isolated from an Indonesian ma�rine sponge of Xestospongia sp. The chemical structure of 1 was determined on the basis of the spectroscopic analysis and comparison with the synthesized 1 and its analogues. Compound 1 showed the cytotoxic activity against PANC-1 cells under the condition of glucose starvation with IC50 value of 16 µM, whereas no growth�inhibition was observed up to 100 µM under the general culture conditions.

Item Type: Other
Subjects: Q Science > Q Science (General)
Depositing User: Dr. Andi Setiawan
Date Deposited: 15 Feb 2022 01:11
Last Modified: 15 Feb 2022 01:11
URI: http://repository.lppm.unila.ac.id/id/eprint/39230

Actions (login required)

View Item View Item