Arai, Masayoshi and Kamiya, Kentaro and Shin, Dayoung and Matsumoto, Hirokazu and Hisa, Tomoya and Setiawan, Andi and Kotoku, Naoyuki and Kobayashi, Motomasa N-Methylniphatyne A, a New 3-Alkylpyridine Alkaloid as an Inhibitor of the Cancer Cells Adapted to Nutrient Starvation, from an Indonesian Marine Sponge of Xestospongia sp. The Pharmaceutical Society of Japan.

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Abstract

n the course of searching for selective growth inhibitors of the cancer cells adapted to nutrient starva�tion, a new 3-alkylpyridine alkaloid named N-methylniphatyne A (1) was isolated from an Indonesian ma�rine sponge of Xestospongia sp. The chemical structure of 1 was determined on the basis of the spectroscopic analysis and comparison with the synthesized 1 and its analogues. Compound 1 showed the cytotoxic activity against PANC-1 cells under the condition of glucose starvation with IC50 value of 16 µM, whereas no growth�inhibition was observed up to 100 µM under the general culture conditions.

Item Type:	Other
Subjects:	Q Science > Q Science (General)
Depositing User:	Prof Andi Setiawan
Date Deposited:	15 Feb 2022 01:11
Last Modified:	15 Feb 2022 01:11
URI:	http://repository.lppm.unila.ac.id/id/eprint/39230

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