Arai, Masayoshi and Yamano, Yoshi and fujita, mayumi and Setiawan, Andi and Kobayashi, Motomasa Stylissamide X, a new proline-rich cyclic octapeptide as an inhibitor of cell migration, from an Indonesian marine sponge of Stylissa sp. Elsevier Ltd..

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Abstract

A new proline-rich cyclic octapeptide named stylissamide X (1) was isolated from an Indonesian marine sponge of Stylissa sp. as an inhibitor of cell migration from the guidance of wound-healing assay. The chemical structure of stylissamide X (1) was determined on the basis of spectroscopic analysis, and stereostructure of the amino acids were deduced by Marfey’s method. Compound 1 showed inhibitory activity against migration of HeLa cells in the ranges of 0.1–10 lM concentration through both wound-healing assay and chemotaxicell chamber assay, while the cell viability was maintained more than 75% up to 10 lM concentration of 1.

Item Type:	Other
Subjects:	Q Science > Q Science (General)
Depositing User:	Prof Andi Setiawan
Date Deposited:	14 Feb 2022 01:46
Last Modified:	14 Feb 2022 01:46
URI:	http://repository.lppm.unila.ac.id/id/eprint/39178

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