Arai, Masayoshi and Kawachi, Takashi and Setiawan, Andi and Kobayashi, Motomasa Hypoxia-Selective Growth Inhibition of Cancer Cells by Furospinosulin-1, a Furanosesterterpene Isolated from an Indonesian Marine Sponge. Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

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Abstract

It is generally accepted that cancer cells, which have adapted to the hypoxic environments in tumor tissues, aggravate cancer pathology by promoting tumor growth, angiogenesis, metastasis, and drug resistance. Therefore, compounds that se�lectively inhibit the growth of tumor cells in hypoxic environ�ments are expected to provide new leads for promising anti�cancer drugs. Furospinosulin-1, a marine-sponge-derived fura�nosesterterpene, exhibited selective antiproliferative activity against DU145 human prostate cancer cells under hypoxic con�ditions in concentrations ranging from 1 to 100 mm. Furospino�sulin-1 also demonstrated antitumor activity at 10–50 mg kg�1 oral administration in a mouse model inoculated with sarcoma S180 cells. Mechanistic analysis revealed that furospinosulin-1 suppresses transcription of the insulin-like growth factor-2 gene (IGF-2), which is selectively induced under hypoxic condi�tions through prevention of the binding of nuclear proteins to the Sp1 consensus sequence in the IGF-2 promoter region

Item Type: Other
Subjects: Q Science > Q Science (General)
Depositing User: Dr. Andi Setiawan
Date Deposited: 14 Feb 2022 01:46
Last Modified: 14 Feb 2022 01:46
URI: http://repository.lppm.unila.ac.id/id/eprint/39176

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