sirait, Christi Natalia and mustofa, syazili (2021) Diagnosis and Management of Peripheral Artery Disease. Majority, 10 (1). pp. 45-54. ISSN 2337-3776
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Abstract
eripheral artery disease (PAD) is one of the most prevalent conditions, and it frequently coexists with vascular disease in other parts of the body. Early diagnosis is important for improving the patient’s quality of life and for reducing the risk of serious secondary vascular events such as acute myocardial infraction (AMI) or stroke. The best noninvasive measure for identifying the presence of occlusive arterial disease is the ankle-brachial index. Lower extremity PAD most frequently presents with pain during ambulation, which is known as “intermittent claudication”. Some relief of symptoms is possible with exercise, pharmacotherapy, and cessation of smoking. The occurrence of PAD is caused by insufficiency in the arteries due to the occurrence of the atherosclerosis process. Aspirin inhibits platelet synthesis through irreversible acetylation of cyclooxygenase (COX) enzymes on platelets. Because platelets do not have a nucleus, platelets are not able to form (COX) enzymes during their lifetime. As a result, the synthesis of thromboxane A2 (TXA2) which plays a major role in platelet aggregation is inhibited. Thus, long-term aspirin in the long term can prevent myocardial infarction and PAD.
| Item Type: | Article |
|---|---|
| Subjects: | R Medicine > R Medicine (General) |
| Divisions: | Fakultas Kedokteran (FK) > Prodi Pendidikan Dokter |
| Depositing User: | Dr.Si. dr. Syazili Mustofa |
| Date Deposited: | 03 Nov 2021 09:27 |
| Last Modified: | 03 Nov 2021 09:27 |
| URI: | http://repository.lppm.unila.ac.id/id/eprint/34916 |
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