Hadi, Sutopo and Suhartati, Tati and Qudus, Hardoko Insan and Rilyanti, Mita and Herasari, Dian and Yandri, Yandri (2021) Synthesis and comparative study on the antibacterial activity organotin(IV) 3-hydroxybenzoate compounds. Pure and Applied Chemistry, 93 (6). ISSN 1365-3075 (In Press)

Hadi et al.10.1515_pac-2020-1103.pdf

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The synthesis and comparative study on the antibacterial activity of three organotin(IV) compounds, namely dibutyltin(IV) bis-(3-hydroxybenzoate), [Bu2Sn(3-HBz)2] (7), diphenyltin(IV) bis-(3-hydroxybenzoate), [Ph2Sn(3-HBz)2] (8), and triphenyltin(IV) 3-hydroxybenzoate, [Ph3Sn(3-HBz)] (9) which were prepared by the reaction of dibutyltin(IV) oxide, [Bu2SnO] (4), diphenyltin(IV) dihydroxide, [Ph2Sn(OH)2] (5), and triphenyltin(IV) hydroxide, [Ph3SnOH] (6) with 3-hydroxybenzoic acid (3-HBz) has successfully been performed. The characterization of these compounds were done using 1H and 13C NMR, IR, UV spectroscopies and their compositions were determined based onmicroanalytical data. Antibacterial activity of these compounds was demonstrated at concentrations of 1.89 × 10−4, 1.81 × 10−4, and 1.72 × 10−4M, respectively by dilution method against Pseudomonas aeruginosa. Similarly, the compounds were active at concentrations of 1.87 × 10−4, 1.79 × 10−4, and 1.71 × 10−4 M, respectively, against Bacillus subtilis. These activities are comparable to that of streptomycin at a concentration of 1.70 × 10−4 M as a positive control, but the halozone of compounds 7, 8, and 9 were slightly lower than that of streptomycin’s halozone. The results obtained suggest that the compounds synthesized have potential as antibacterial agents.

Item Type: Article
Uncontrolled Keywords: Antibacterial activity; B. subtilis; chemistry and its applications; organotin(IV) 3-hydroxybenzoate; P. Aeruginosa; VCCA-2020.
Subjects: Q Science > QD Chemistry
Divisions: Fakultas Matematika dan Ilmu Pengetahuan Alam (FMIPA) > Prodi Kimia
Depositing User: Prof. Sutopo Hadi
Date Deposited: 21 Jun 2021 01:08
Last Modified: 21 Jun 2021 01:08
URI: http://repository.lppm.unila.ac.id/id/eprint/32703

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