Arai, Masayoshi and Shin, Dayoung and Kamiya, Kentaro and Ishida, Ryosuke and Setiawan, Andi and Kotoku, Naoyuki and Kobayashi, Motomasa (2016) Marine spongean polybrominated diphenyl ethers, selective growth inhibitors against the cancer cells adapted to glucose starvation, inhibits mitochondrial complex II. J Nat Med, 71 (1). pp. 44-49. ISSN 13403443, 18610293

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In the course of search for selective growth inhibitors against the cancer cells adapted to nutrient starvation, two polybrominated diphenyl ethers, 3,4,5-tri�bromo-2-(20 ,40 -dibromophenoxy)-phenol (1) and 3,5-di�bromo-2-(20 ,40 -dibromophenoxy)-phenol (2) were isolated from an Indonesian marine sponge of Dysidea sp. Com�pounds 1 and 2 showed the anti-proliferative activity against PANC-1 cells under glucose-starved conditions with IC50 values of 2.1 and 3.8 lM, respectively, whereas no growth inhibition was observed up to 30 lM in the general culture conditions. The further mechanistic analy�sis indicated that compound 1 might act mainly by inhibiting complex II in the mitochondrial electron trans�port chain. Keywords Polybrominated diphenyl ether � Marine sponge � Cancer � Glucose starvation � Mitochondrial electron transport chain

Item Type: Article
Subjects: Q Science > Q Science (General)
Divisions: Fakultas Matematika dan Ilmu Pengetahuan Alam (FMIPA) > Prodi Kimia
Depositing User: Prof Andi Setiawan
Date Deposited: 09 Jun 2021 01:29
Last Modified: 09 Jun 2021 01:29

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