Arai, Masayoshi and Yamano, Yoshi and fujita, mayumi and Setiawan, Andi and Kobayashi, Motomasa (2012) Stylissamide X, a new proline-rich cyclic octapeptide as an inhibitor of cell migration, from an Indonesian marine sponge of Stylissa sp. Bioorganic & Medicinal Chemistry Letters, 22 (4). pp. 1818-1821. ISSN 0960894X, 14643405

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A new proline-rich cyclic octapeptide named stylissamide X (1) was isolated from an Indonesian marine sponge of Stylissa sp. as an inhibitor of cell migration from the guidance of wound-healing assay. The chemical structure of stylissamide X (1) was determined on the basis of spectroscopic analysis, and stereostructure of the amino acids were deduced by Marfey’s method. Compound 1 showed inhibitoryactivity against migration of HeLa cells in the ranges of 0.1–10 lM concentration through both wound-healing assay and chemotaxicell chamber assay, while the cell viability was maintained more than 75% up to 10 lM concentration of 1

Item Type: Article
Subjects: Q Science > Q Science (General)
Divisions: Fakultas Matematika dan Ilmu Pengetahuan Alam (FMIPA) > Prodi Kimia
Depositing User: Prof Andi Setiawan
Date Deposited: 08 Jun 2021 16:21
Last Modified: 08 Jun 2021 16:21

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