Sumii, Yuji and Kotoku, Naoyuki and Han, Chisu and Kamiya, Kentaro and Setiawan, Andi and Vilchèze, Catherine and . Jacobs Jr, William R and Arai, Masayoshi (2020) 3-(Phenethylamino)demethyl(oxy)aaptamine as an anti-dormant mycobacterial substance: Isolation, evaluation and total synthesis. Tetrahedron Letters, 61. pp. 1-4. ISSN 00404039, 18733581

[img]
Preview
Text
sumii2020.pdf

Download (596kB) | Preview
Official URL: https://pubmed.ncbi.nlm.nih.gov/32577043/

Abstract

3-(Phenethylamino)demethyl(oxy)aaptamine (1) was re-discovered from the marine sponge of Aaptos sp. as an anti-dormant mycobacterial substance through the bioassay-guided separation. Compound 1 showed potent anti-microbial activity against Mycobacterium bovis BCG with a minimum inhibitory concentration of 0.75 mg/mL under both aerobic conditions and hypoxic conditions inducing dormant state. Compound 1 was also effective against pathogenic M. tuberculosis strains including clinical multidrugresistant strains. Furthermore, the successful total syntheses of 1 and its analog 3-aminodemethyl(oxy) aaptamine (2) afford sufficient quantities for further biological studies.

Item Type: Article
Subjects: Q Science > Q Science (General)
Divisions: Fakultas Matematika dan Ilmu Pengetahuan Alam (FMIPA) > Prodi Kimia
Depositing User: Dr. Andi Setiawan
Date Deposited: 08 Jun 2021 16:18
Last Modified: 08 Jun 2021 16:18
URI: http://repository.lppm.unila.ac.id/id/eprint/32339

Actions (login required)

View Item View Item